Amphetamine is known to inhibit monoamine oxidase, whereas the power of amphetamine and its metabolites to inhibit a variety of P450 isozymes and various enzymes hasn't been sufficiently elucidated. In vitro experiments with human microsomes show insignificant inhibition of CYP2D6 by amphetamine and minor inhibition of CYP1A2, 2D6, and 3A4 by one o